Methyl glucoside-6-phosphate

Methyl glucoside-6-phosphate (C7H13O9P2) is a structural analog to glucose-6- phosphate that plays an important role in cellular bioenergetics. Dietary glucose is converted to glucose phosphate that can diffuse into the cells to provide the energy needed for cellular metabolism. It is one of the important members of the Krebs cycle (glucose metabolism inside the cell or glycolysis) producing ATP molecules required for many biological reactions to occur in the body.1

In the case of skin, cellular energy is needed to maintain the dermal architecture towards the synthesis of collagen, elastin, stimulation of fibroblasts, synthesis of ECM components, etc. With age, the fibroblasts become senescent resulting in lower levels of collagen, elastin, and ECM components due to decreased cellular energy levels. 1 Methyl glucoside-6-phosphate provides readily available diffusible energy to the fibroblasts to stimulate the synthesis of collagen, elastin, and ECM components. Lysine is an essential amino acid, which means that human cells cannot produce it, but it’s a necessary building block for collagen and elastin. It is involved in the synthesis and cross linking of collagen polypeptides. Proline is a non-essential amino acid, human cells can produce it, but fibroblasts spend a lot of it (about 10% of the collagen chain is proline). Copper ions are required for the Lysyl oxidase enzyme (copper is in the active domain or acting site of that enzyme) involved in the extracellular maturation (crosslinking of proteins) of collagen and elastin. 2,3,4,5

Together with proline, lysine, and copper that is needed for the synthesis of collagen and elastin, methyl glucoside-6-phosphate has been proven clinically to stimulate fibroblasts towards the synthesis of these dermal structural proteins. An increase in collagen and elastin production by 6.9 and 190% in just 11 days of usage was observed. A d ecrease in the depth of the wrinkles was also seen along with improved skin hydration and a soft feel.6

References:

  1. Formation of Connective Tissue Nutrition Reviews, Volume 31, Issue 1, January 1973, Pages 28–29.
  2. Proline-dependent regulation of collagen Cellular and Molecular Life Sciences, 2020,1911–1918.
  3. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters, Volume 238, number 2, 343-346.
  4. Cancer-Associated Fibroblasts Stimulated by Transforming Growth Factor,  Beta1 TGF-Beta Increase Invasion Rate of Tumor Cells: A Population Breast Cancer Res Treat (2008) 110:39–49. doi: 10.1007/s10549-007- 9684-7.
  5. Transforming Growth Factor Type Beta: Rapid Induction of Fibrosis and angiogenesis in vivo and in stimulation of collagen in vitro. Proc Natl Acad Sci, 1986, June(84), pg4161.
  6. SKINCAREPREPARATIONS, : US10,124,030B2 (45)DateofPatent: Nov.13,2018